European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2016
Acute inflammatory demyelinating polyradiculoneuropathy in a newborn infant.
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Anastasopoulou Stavroula, Lindefeldt Marie, Bartocci Marco, Wickström Ronny
Аннотация
BACKGROUND: Acute inflammatory demyelinating polyneuropathy (AIDP), also known as Guillain-Barré syndrome, is an immune-mediated polyneuropathy usually triggered by infections or vaccinations. In childhood AIDP is commonly described after the first year of life. Here, we present a case of a newborn infant with AIDP manifestation directly after delivery.
CASE STUDY: A newborn girl with a healthy mother, without known exposure to immunomodulating factors, was admitted to the neuropediatric department due to ascending hypotonia, weakness, pain and areflexia in the lower extremities. The clinical presentation, laboratory and neurophysiological studies supported the diagnosis of AIDP. The infant showed first signs of clinical improvement following administration of intravenous immunoglobulin and her recovery was complete at one year.
CONCLUSION: AIDP should be considered as a differential diagnosis in ascending hypotonia also in the neonatal period.
CASE STUDY: A newborn girl with a healthy mother, without known exposure to immunomodulating factors, was admitted to the neuropediatric department due to ascending hypotonia, weakness, pain and areflexia in the lower extremities. The clinical presentation, laboratory and neurophysiological studies supported the diagnosis of AIDP. The infant showed first signs of clinical improvement following administration of intravenous immunoglobulin and her recovery was complete at one year.
CONCLUSION: AIDP should be considered as a differential diagnosis in ascending hypotonia also in the neonatal period.