[Effect of merkazolyl on the level of thyrostimulating immunoglobulins of the blood in patients with diffuse toxic goiter].

A study was made of the level of thyrostimulating immunoglobulins (TSI) in the blood of 31 untreated patients with diffuse toxic goiter (DTG). The effect of thiamazole applied at a daily dose of 30-60 mg for 3-4 weeks on a TSI level was investigated in 18 patients. The level was assessed by an increase in a cAMP level in thyroid paired lobes after incubation with immunoglobulins of DTG patients. The basal level of TSI does not correlate with the level of blood thyroxin, thyroid iodine absorptive capacity of DTG patients, and severity of thyrotoxicosis. Thiamazole produces a different effect depending on a degree of severity of thyrotoxicosis decreasing a TSI level in patients with disease of average severity and not changing the level in severe thyrotoxicosis.