Emerging infectious diseases · 2021
Territorywide Study of Early Coronavirus Disease Outbreak, Hong Kong, China.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Leung Kenneth Siu-Sing, Ng Timothy Ting-Leung, Wu Alan Ka-Lun, Yau Miranda Chong-Yee, Lao Hiu-Yin, Choi Ming-Pan, Tam Kingsley King-Gee, Lee Lam-Kwong, Wong Barry Kin-Chung, Man Ho Alex Yat, Yip Kam-Tong, Lung Kwok-Cheung, Liu Raymond Wai-To, Tso Eugene Yuk-Keung, Leung Wai-Shing, Chan Man-Chun, Ng Yuk-Yung, Sin Kit-Man, Fung Kitty Sau-Chun, Chau Sandy Ka-Yee, To Wing-Kin, Que Tak-Lun, Shum David Ho-Keung, Yip Shea Ping, Yam Wing Cheong, Siu Gilman Kit-Hang
Аннотация
Initial cases of coronavirus disease in Hong Kong were imported from mainland China. A dramatic increase in case numbers was seen in February 2020. Most case-patients had no recent travel history, suggesting the presence of transmission chains in the local community. We collected demographic, clinical, and epidemiologic data from 50 patients, who accounted for 53.8% of total reported case-patients as of February 28, 2020. We performed whole-genome sequencing to determine phylogenetic relationship and transmission dynamics of severe acute respiratory syndrome coronavirus 2 infections. By using phylogenetic analysis, we attributed the community outbreak to 2 lineages; 1 harbored a common mutation, Orf3a-G251V, and accounted for 88.0% of the cases in our study. The estimated time to the most recent common ancestor of local coronavirus disease outbreak was December 24, 2019, with an evolutionary rate of 3.04 × 10-3 substitutions/site/year. The reproduction number was 1.84, indicating ongoing community spread.