Fatal ventricular fibrillation after treatment with digoxin in a 27-year-old man with mitral leaflet prolapse syndrome.

A 27-year-old man with typical mitral leaflet prolapse syndrome was under medical care for eight years with ventricular arrhythmias resistant to various antiarrhythmic drugs. He was started on digoxin, 0.25 mg daily, because of echocardiographically demonstrated left ventricular dilatation and functional impairment; he died of ventricular fibrillation 15 days later.