Prevalence of Getah Virus in Mammals in East and Southeast Asia: A Systematic Review and Meta-Analysis.

Getah virus (GETV) has reemerged as an important mosquito-borne pathogen affecting livestock health in East and Southeast Asia. To quantify its epidemiological patterns, we conducted a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-compliant meta-analysis of literature published between 2000 and September 2025. Analysis of 24 observational studies covering swine, equine, bovine, caprine, and wildlife populations using a random-effects model revealed a pooled mammalian seroprevalence of 26% (95% confidence interval [CI]: 0.17-0.38) and a pooled nucleic acid positivity rate of 2% (95% CI: 0.01-0.05), consistent with broad past exposure but limited detection of active viremia in cross-sectional surveys. Swine were identified as the main amplifying hosts, particularly in intensive farming regions of eastern and southern China, where herd seropositivity exceeded 60%. Results indicate a significant prevalence increase over the past 25 years. The established mosquito-swine-mosquito transmission cycle confirms GETV has transformed from a sporadic pathogen into a persistent threat within intensive farming environments.