Alzheimer's & dementia (New York, N. Y.) · 2016
The roles of inflammation and immune mechanisms in Alzheimer's disease.
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Van Eldik Linda J, Carrillo Maria C, Cole Patricia E, Feuerbach Dominik, Greenberg Barry D, Hendrix James A, Kennedy Matthew, Kozauer Nick, Margolin Richard A, Molinuevo José L, Mueller Reinhold, Ransohoff Richard M, Wilcock Donna M, Bain Lisa, Bales Kelly
Аннотация
The Alzheimer's Association's Research roundtable met in April 2015 to explore the role of neuroinflammatory mechanisms in the progression of Alzheimer's disease (AD). The ability of innate immune cells, particularly microglia and astrocytes, to mediate neuroinflammation in AD has been implicated as a significant contributor to disease pathogenesis. Adaptive immunity, which plays an important role in responding to injury and some diseases of the central nervous system, may contribute to neuroinflammation in AD as well. Communication between the central and peripheral immune systems may also be important in AD. An increased understanding of the physiology of the innate immune system may aid the identification of new therapeutic targets or mechanisms. The development of predictive animal models and translatable neuroinflammation biomarkers for AD would also facilitate the advancement of novel treatments for innate immunity. Important challenges impeding the advancement of new therapeutic agents and strategies to overcome them were discussed.