A study on the correlation between novel metabolic and inflammatory-derived indicators (TyG, THR, NHR, UHR) and overweight older adult patients with T2DM.

OBJECTIVE

To evaluate the correlation between novel metabolic and inflammatory-derived Indicators (TyG, THR, NHR, UHR) for overweight in older adult type 2 diabetes mellitus (T2DM) patients.

METHODS

This study enrolled 183 hospitalized older adult T2DM patients (aged ≥ 60 years) from 2023 to 2024. Participants were stratified into overweight (24 ≤ BMI < 28, n = 85) and normal-weight groups (18.5 ≤ BMI < 24, n = 98). Clinical parameters including TyG, THR, NHR, and UHR were calculated. Statistical analyses involved t-tests, logistic regression, Spearman correlation, and ROC curves.

RESULTS

Key metabolic/inflammatory derived indices (TyG, THR, NHR, UHR) were significantly elevated in overweight group versus normal group (all P < 0.05). BMI showed positive correlations with TyG, THR, NHR, and UHR (all P < 0.05). Logistic regression confirmed the TyG, THR, NHR and UHR index are significantly associated with the development of overweight in T2DM patients (all P < 0.05). After adjusting for confounders, TyG demonstrated the highest predictive accuracy for overweight status (AUC = 0.732), followed by THR, NHR and UHR.

CONCLUSION

TyG, THR, NHR and UHR are significantly associated with overweight in older adult T2DM, potentially serving as simple screening tools for early metabolic risk stratification and weight management.