Seminal parameters of patients with Type 2 Diabetes Mellitus undergoing Assisted Reproduction: A retrospective analysis.

OBJECTIVE

This study aims to investigate the impact of T2DM on the seminal parameters of patients undergoing assisted reproduction techniques.

METHODS

A retrospective analysis of medical records was conducted at the at our institution from January 2017 to January 2022, including data on patients age, presence of Type 1 or T2DM, prediabetes, and seminal parameters such as concentration, Kruger morphology, motility, pH, ejaculate volume, and sperm DNA fragmentation.

RESULTS

Seminal parameters of patients with T2DM did not show significant differences compared to patients with normal controls. Conversely, evaluation of HbA1c as a continuous variable in our linear regression model indicated that this parameter was associated with elevated sperm DNA fragmentation.

CONCLUSIONS

T2DM was not found to be a determining factor in the deterioration of overall seminal quality in patients undergoing assisted reproduction techniques, with a potential negative effect on sperm DNA fragmentation.