Cyclosporine and ketoconazole for the treatment of perianal fistulas in dogs.

OBJECTIVE

To evaluate efficacy and cost of using cyclosporine and ketoconazole for the treatment of perianal fistulas in dogs.

DESIGN

Clinical trial.

ANIMALS: 12 dogs with perianal fistulas.

PROCEDURE: Dogs received cyclosporine and ketoconazole orally (target whole blood trough cyclosporine concentrations of 400 to 600 ng/ml). Study endpoints were resolution of clinical signs, remission, and recurrence of disease. Adverse effects and cost of medications were reported. Results were compared with those from previous studies in humans and in dogs in which single agent cyclosporine treatment for perianal fistulas was used.

RESULTS

All dogs had resolution of clinical signs. Eight dogs went into remission; however, 5 of those 8 had recurrence of fistulas. Adverse effects of treatment were minimal and well tolerated. Cost of treatment was comparable to traditional surgical options and less than single agent cyclosporine treatment.

CONCLUSIONS AND CLINICAL RELEVANCE: Administration of cyclosporine with ketoconazole is an effective and cost-comparable treatment for perianal fistulas in dogs.