Effect of cinnamon and statins drug on kidney and liver of rats receiving gentamicin.

UNLABELLED: The aim of this study is to examine the effects of cinnamon and statins on the renal and liver functions of gentamicin-received rats.

METHODS

Forty male albino rats were recruited into 4 groups (10 rat each) for a 21-day period by gavage treatment. The control group 1 was given nothing but 0.5 ml normal saline, and others injected with a dose of 100 mg/kg of Gentamicin intraperitoneally for one week before treatment. Group 2 received Gentamicin alone, Group 3 received an aqueous extract of cinnamon, and Group 4 treated with a statin medication.

RESULTS

Gentamicin-treated group compared to other groups showed a significant increase in lever and kidney enzymes. The group treated with cinnamon or statin revealed noticeable positive effects on these markers, whereas statin showed decrease in Alanine Aminotransferase ALT levels.

CONCLUSION

Parameters of hepatotoxicity and nephrotoxicity induced by gentamicin were significantly reserved by cinnamon or statin, statin less effective.