[Histochemical study of enzyme activity of the exocrine and endocrine pancreas at different glucocorticoid levels in animal body].

A comparative study was made of the activity of nonspecific phosphatases and lactate dehydrogenases, succinate and NADH in exocrine and endocrine pancreas in excess and deficiency of body glucocorticoids. SDH, NADH-DH and LDH activity in pancreatic acinar cells was shown to be higher than that in the endocrine epithelium but significantly lower than the activity of nonspecific phosphatases, acid phosphatase being the predominant enzyme of B-insulocytes and alkaline phosphatase the predominant enzyme of A-insulocytes. A stimulating effect of hydrocortisone physiological doses on pancreatic secretory activity was accompanied by the enhanced activity of nonspecific phosphatases and enzymes of the Krebs cycle in the exocrine epithelium and acid phosphatase, NADH-DH in B-insulocytes. Large hydrocortisone doses as well as hormonal balance deficiency resulted in a decrease in the energy potential of acinar and endocrine cells.