Risk of intestinal involvement in mucocutaneous-onset Behçet's disease: data from the AIDA network registry.
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Vitale Antonio, Caggiano Valeria, Sbalchiero Jessica, Gavioli Francesco, Lopalco Giuseppe, Ragab Gaafar, Guerriero Silvana, Almaglouth Ibrahim, Tufan Abdurrahman, Giacomelli Roberto, Direskeneli Haner, Ruscitti Piero, Hatemi Gülen, Carubbi Francesco, Batu Ezgi Deniz, Ozen Seza, Sota Jurgen, Giardini Henrique Ayres Mayrink, Frassi Micol, Sfikakis Petros P, Morrone Maria, Gatti Federica, Maher Amina, Mahmoud Ayman Abdel-Monem Ahmed, Dammacco Rosanna, Kucuk Hamit, Kardas Riza Can, Cakir Ibrahim Yahya, Corcia Letizia Pia di, Öner Fatma Alibaz, Sevik Gizem, Gentile Martina, Karakoc Alican, Alunno Alessia, Emreol Hulya Ercan, Crisafulli Francesca, Tektonidou Maria, Ciccia Francesco, Thabet Maissa, Bugatti Serena, Milanesi Alessandra, Chimenti Maria Sole, Monosi Benedetta, Piga Matteo, Floris Alberto, Hinojosa-Azaola Andrea, Guaracha-Basañez Guillermo Arturo, Chighizola Cecilia Beatrice, Hernández-Rodríguez José, Cattalini Marco, Govoni Marcello, Viapiana Ombretta, Civino Adele, Opris-Belinski Daniela, Gaggiano Carla, Talarico Rosaria, Giardina Annarita, Emmi Giacomo, Puttini Piercarlo Sarzi, Maggio Maria Cristina, Parronchi Paola, Portincasa Piero, de-la-Torre Alejandra, Cardona-López Juanita, Gentileschi Stefano, Mauro Angela, Sebastiani Gian Domenico, Gicchino Maria Francesca, Şahin Ali, Rigante Donato, Bilgin Emre, Del Giudice Emanuela, Breda Luciana, De Paulis Amato, Lo Gullo Alberto, Erten Şükran, Tharwat Samar, Fotis Lampros, Armin Maier, Insalaco Antonella, Karamanakos Anastasios, Conforti Alessandro, Gündüz Özgül Soysal, Moshrif Abdelhfeez, Li Gobbi Francesca, Costi Stefania, Bartoloni Elena, Barone Patrizia, Guiducci Serena, González-García Andrés, Rodriguez Inés Hernanz, Conti Giovanni, Iagnocco Annamaria, Önen Fatos, Al-Mayouf Sulaiman M, Hatemi Ali İbrahim, Balistreri Alberto, Fabiani Claudia, Cantarini Luca
Аннотация
METHODS: Data were obtained from the International AutoInflammatory Disease Alliance Network registry dedicated to BD; a Bayesian statistical approach was employed to address the limited sample size resulting from subgroup stratifications.
RESULTS: In total, 328 BD patients with exclusively mucocutaneous onset were enrolled; of these, 46 (14%) developed intestinal involvement over time. The risk of ocular involvement was higher among patients with intestinal manifestations (OR: 3.02, 95% CrI: 1.24-6.08; posterior probability: 99.3%). Minor aphthous ulcers without major aphthosis were protective towards intestinal involvement (OR: 0.47, 95% CrI: 0.22-0.98; posterior probability: 97.98%). Conversely, major aphthous ulcers increased the risk (OR: 3.25, 95% CrI: 1.50-7.02; posterior probability: 99.7%), along with the combination of oral major aphthosis with: i) genital aphthosis (OR = 2.77, 95%CrI: 1.14-6.58; posterior probability: 98.45%); ii) pseudofolliculitis (OR = 3.18, 95%CrI: 1.15-8.33; posterior probability: 98.72%); iii) genital aphthosis plus pseudofolliculitis (OR = 5.22, 95%CrI: 1.71-16.35; posterior probability of 99.77%). Pseudofolliculitis plus cutaneous manifestations other than erythema nodosum were protective against intestinal involvement (OR = 0.01, 95%CrI: 0.0-0.98; posterior probability: 97.55%).
CONCLUSION: Major aphthosis was the strongest factor associated with intestinal involvement in BD patients initially presenting with mucocutaneous symptoms only. In such patients, intestinal involvement correlated with increased risk of ocular inflammation.