Trypanocidal action of p-biguanidoacetophenone amidinohydrazone.

p-Biguanidoacetophenone amidinohydrazone, given in single doses, can cure mice infected with an old laboratory strain of Trypanosoma rhodesiense, but it has only slight action on more recently isolated strains. Trypanosomes which are resistant to stilbamidine are resistant to this compound also. Apparently its trypanocidal action is similar to that of the diamidine series of trypanocidal compounds.