Association of the new TyG indicator-TyHGB with prediabetes and diabetes in middle-aged and elderly postmenopausal women: a longitudinal study.

INTRODUCTION

Given the established relationship between lipid metabolism and dysglycemia, this longitudinal study aimed to investigate the association between the triglyceride-high density lipoprotein cholesterol-glucose body index (TyHGB) and the risk of developing prediabetes or diabetes among middle-aged and elderly postmenopausal women.

METHODS

Data were collected from the REACTION study in Dalian, China. The study included postmenopausal women with normal baseline glucose tolerance who were followed up over a three-year period. We used multivariable logistic regression to evaluate the relationship of TyHGB with incident prediabetes and diabetes. Restricted cubic splines (RCS) were employed to examine dose-response relationships. The predictive performance of TyHGB and traditional indices for prediabetes and diabetes was evaluated and compared using receiver operating characteristic (ROC) curve analysis.

RESULTS

Among the 2,138 postmenopausal women with normal glucose levels at baseline, 598 developed prediabetes and 124 developed diabetes during the follow-up period. Multivariable logistic regression revealed a significant positive association between TyHGB and the risk of both prediabetes and diabetes. Restricted cubic spline analysis confirmed a nonlinear dose-response relationship, with prediabetes risk increasing steeply below an inflection point of 8.52 before plateauing, whereas diabetes risk remained stable below 6.47 and increased sharply thereafter. Subgroup analyses demonstrated that this association remained consistent across strata defined by age, hypertension, hyperlipidemia, and coronary heart disease (CHD). Additional ROC curve analyses suggested that TyHGB may provide effective predictive value for diabetes in postmenopausal women.

CONCLUSION

In a middle-aged and elderly postmenopausal population, the TyHGB index is a significant independent risk factor for prediabetes and diabetes.