Management of isolated gingival recession defects using platelet rich fibrin and amnio-chorion membrane in coronally advanced flap: an in-vivo study.

Gingival recession is a highly prevalent mucogingival condition that can significantly compromise oral health and esthetics. Patients commonly suffer from dentinal hypersensitivity, root caries, poor esthetics, discomfort during brushing, and in severe cases tooth mobility or tooth loss, ultimately affecting their quality of life. To compare the effectiveness of Platelet Rich Fibrin (PRF) and Amnio-Chorion Membrane (ACM) with Coronally Advanced Flap (CAF) to manage the case of isolated gingival recession defects (GRD). The study is a split-mouth randomised trial that included 13 patients (n = 26) with bilateral Miller Class 1 or 2 maxilla anterior and premolar recession of the gingiva. The randomizing of locations was also done to 13 sites in each group of either Group I (CAF+ PRF, n = 13) or Group II (CAF +ACM, n = 13). At 6 months follow-up, plaque Index (PI), Gingival Index (GI), Probing pocket depth (PPD), gingival recession depth (GRD), Clinical attachment level (CAL), Keratinized gingiva width (WKG), Percentage of root coverage, and root coverage Esthetic score (RES) were measured. All data were analyzed in the SPSS v21.0 software; paired t-tests and unpaired t-tests were used for comparing the intragroup and intergroup respectively. The level of statistical significance was defined as p < 0.05. At 6 months, statistically significant improvements in PRF and CAM in all clinical parameters was seen. Root coverage of Group I was 78.84 ± 19.13 and Group II was 74.99 ± 15.59. Intergroup comparisons showed no statistically significance in clinical outcome, RES or root coverage percentage (p > 0.05). PRF and ACM had both positive outcomes on gingival thickness, WKG, and CAL. PRF or ACM resulted in significant improvement in clinical periodontal parameters, root coverage, and esthetic outcomes, with no statistically significant difference between the two groups.