Sodium chloride treatment of antidepressant-induced orthostatic hypotension.

Orthostatic hypotension, a serious, frequent side effect of antidepressant medication, can be severe enough to require cessation of medication. The authors report three cases of antidepressant-induced orthostatic hypotension treated with sodium chloride. In two of the cases, the use of sodium chloride allowed the patient to continue antidepressant treatment at a therapeutically effective dosage. The authors discuss risks and treatment of orthostatic hypotension.