International journal of cardiology · 2014
Hypertriglyceridemic waist phenotype and risk of cardiovascular diseases in China: results from the Kailuan Study.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Wang Anxin, Li Zhaoxia, Zhou Yong, Wang Chunxue, Luo Yanxia, Liu Xiaoxue, Guo Xiuhua, Wu Shouling, Zhao Xingquan
Аннотация
BACKGROUND: While some case-control studies have showed the correlation between the hypertriglyceridemic waist (HTGW) phenotype (increased WC and hypertriglyceridemia) and cardiovascular disease (CVD) events, there are few data regarding this correlation in cohort studies, especially in Asian populations that have a higher prevalence of central obesity than other populations.
OBJECTIVE: The aim of this study was to explore the relationship between HTGW phenotype and risk of incident CVD events among men and women in China.
METHODS: We analyzed 95,015 participants (18-98 years old) in the Kailuan Study. CVDs developed in 1958 people during follow-up. The cutoffs for defining HTGW phenotype were a waist circumference (WC) of 90 cm or more and a triglyceride level of 2.0 mmol/L or more for men and a WC of 85 cm or more and a triglyceride level of 1.5 mmol/L or more for women. Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated from Cox regression models.
RESULTS: Compared with participants who had a normal WC and a normal triglyceride level (NWNT), those with HTGW phenotype had a higher WC, body mass index, prevalence of hypertension and diabetes mellitus; and a lower level of high-density lipoprotein cholesterol. The HTGW group had an unadjusted HR of 1.76 (95% CI=1.55-1.99) for future CVDs compared with the NWNT group. After adjustment for confounders, the HR still remained significant (HR=1.24, 95% CI=1.07-1.44).
CONCLUSIONS: HTGW phenotype was associated with the risk of CVDs independently. HTGW phenotype might be a simple but useful tool to screen the individuals at a high risk for future CVDs, and it might be recommended in most clinical practices.
OBJECTIVE: The aim of this study was to explore the relationship between HTGW phenotype and risk of incident CVD events among men and women in China.
METHODS: We analyzed 95,015 participants (18-98 years old) in the Kailuan Study. CVDs developed in 1958 people during follow-up. The cutoffs for defining HTGW phenotype were a waist circumference (WC) of 90 cm or more and a triglyceride level of 2.0 mmol/L or more for men and a WC of 85 cm or more and a triglyceride level of 1.5 mmol/L or more for women. Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated from Cox regression models.
RESULTS: Compared with participants who had a normal WC and a normal triglyceride level (NWNT), those with HTGW phenotype had a higher WC, body mass index, prevalence of hypertension and diabetes mellitus; and a lower level of high-density lipoprotein cholesterol. The HTGW group had an unadjusted HR of 1.76 (95% CI=1.55-1.99) for future CVDs compared with the NWNT group. After adjustment for confounders, the HR still remained significant (HR=1.24, 95% CI=1.07-1.44).
CONCLUSIONS: HTGW phenotype was associated with the risk of CVDs independently. HTGW phenotype might be a simple but useful tool to screen the individuals at a high risk for future CVDs, and it might be recommended in most clinical practices.