Journal of occupational and environmental medicine · 2011
Lung pathologic findings in a local residential and working community exposed to World Trade Center dust, gas, and fumes.
СтатьяПоддержка исследования: вне правительства СШАПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
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Caplan-Shaw Caralee E, Yee Herman, Rogers Linda, Abraham Jerrold L, Parsia Sam S, Naidich David P, Borczuk Alain, Moreira Andre, Shiau Maria C, Ko Jane P, Brusca-Augello Geraldine, Berger Kenneth I, Goldring Roberta M, Reibman Joan
Аннотация
OBJECTIVE: To describe pathologic findings in symptomatic World Trade Center-exposed local workers, residents, and cleanup workers enrolled in a treatment program.
METHODS: Twelve patients underwent surgical lung biopsy for suspected interstitial lung disease (group 1, n = 6) or abnormal pulmonary function tests (group 2, n = 6). High-resolution computed axial tomography and pathologic findings were coded. Scanning electron microscopy with energy-dispersive x-ray spectroscopy was performed.
RESULTS: High-resolution computed axial tomography showed reticular findings (group 1) or normal or airway-related findings (group 2). Pulmonary function tests were predominantly restrictive. Interstitial fibrosis, emphysematous change, and small airway abnormalities were seen. All cases had opaque and birefringent particles within macrophages, and examined particles contained silica, aluminum silicates, titanium dioxide, talc, and metals.
CONCLUSIONS: In symptomatic World Trade Center-exposed individuals, pathologic findings suggest a common exposure resulting in alveolar loss and a diverse response to injury.
METHODS: Twelve patients underwent surgical lung biopsy for suspected interstitial lung disease (group 1, n = 6) or abnormal pulmonary function tests (group 2, n = 6). High-resolution computed axial tomography and pathologic findings were coded. Scanning electron microscopy with energy-dispersive x-ray spectroscopy was performed.
RESULTS: High-resolution computed axial tomography showed reticular findings (group 1) or normal or airway-related findings (group 2). Pulmonary function tests were predominantly restrictive. Interstitial fibrosis, emphysematous change, and small airway abnormalities were seen. All cases had opaque and birefringent particles within macrophages, and examined particles contained silica, aluminum silicates, titanium dioxide, talc, and metals.
CONCLUSIONS: In symptomatic World Trade Center-exposed individuals, pathologic findings suggest a common exposure resulting in alveolar loss and a diverse response to injury.
Предметные рубрики MeSH
AdultAir PollutantsAluminum SilicatesBronchiBronchographyDustEnvironmental ExposureFemaleGasesHumansLungLung Diseases, InterstitialMaleMiddle AgedNew York CityOccupational DiseasesPulmonary FibrosisRespiratory Function TestsSeptember 11 Terrorist AttacksSilicon DioxideSpirometryTalcTitaniumTomography, X-Ray Computed