Медицинская библиотека · Nature communications · 2018
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.
Wyss Annah B, Sofer Tamar, Lee Mi Kyeong, Terzikhan Natalie, Nguyen Jennifer N, Lahousse Lies, Latourelle Jeanne C, Smith Albert Vernon, Bartz Traci M, Feitosa Mary F, Gao Wei, Ahluwalia Tarunveer S, Tang Wenbo, Oldmeadow Christopher, Duan Qing, de Jong Kim, Wojczynski Mary K, Wang Xin-Qun, Noordam Raymond, Hartwig Fernando Pires, Jackson Victoria E, Wang Tianyuan, Obeidat Ma'en, Hobbs Brian D, Huan Tianxiao, Gui Hongsheng, Parker Margaret M, Hu Donglei, Mogil Lauren S, Kichaev Gleb, Jin Jianping, Graff Mariaelisa, Harris Tamara B, Kalhan Ravi, Heckbert Susan R, Paternoster Lavinia, Burkart Kristin M, Liu Yongmei, Holliday Elizabeth G, Wilson James G, Vonk Judith M, Sanders Jason L, Barr R Graham, de Mutsert Renée, Menezes Ana Maria Baptista, Adams Hieab H H, van den Berge Maarten, Joehanes Roby, Levin Albert M, Liberto Jennifer, Launer Lenore J, Morrison Alanna C, Sitlani Colleen M, Celedón Juan C, Kritchevsky Stephen B, Scott Rodney J, Christensen Kaare, Rotter Jerome I, Bonten Tobias N, Wehrmeister Fernando César, Bossé Yohan, Xiao Shujie, Oh Sam, Franceschini Nora, Brody Jennifer A, Kaplan Robert C, Lohman Kurt, McEvoy Mark, Province Michael A, Rosendaal Frits R, Taylor Kent D, Nickle David C, Williams L Keoki, Burchard Esteban G, Wheeler Heather E, Sin Don D, Gudnason Vilmundur, North Kari E, Fornage Myriam, Psaty Bruce M, Myers Richard H, O'Connor George, Hansen Torben, Laurie Cathy C, Cassano Patricia A, Sung Joohon, Kim Woo Jin, Attia John R, Lange Leslie, Boezen H Marike, Thyagarajan Bharat, Rich Stephen S, Mook-Kanamori Dennis O, Horta Bernardo Lessa, Uitterlinden André G, Im Hae Kyung, Cho Michael H, Brusselle Guy G, Gharib Sina A, Dupuis Josée, Manichaikul Ani, London Stephanie J
СтатьяМетаанализResearch Support, N.I.H., IntramuralПеревод пока не подготовлен
Аннотация
Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 individuals of European (N = 60,552), African (N = 8429), Asian (N = 9959), and Hispanic/Latino (N = 11,775) ethnicities. We identify over 50 additional loci at genome-wide significance in ancestry-specific or multiethnic meta-analyses. Using recent fine-mapping methods incorporating functional annotation, gene expression, and differences in linkage disequilibrium between ethnicities, we further shed light on potential causal variants and genes at known and newly identified loci. Several of the novel genes encode proteins with predicted or established drug targets, including KCNK2 and CDK12. Our study highlights the utility of multiethnic and integrative genomics approaches to extend existing knowledge of the genetics of lung function and clinical relevance of implicated loci.
Для цитирования: Wyss Annah B, Sofer Tamar, Lee Mi Kyeong, Terzikhan Natalie, Nguyen Jennifer N, Lahousse Lies, Latourelle Jeanne C, Smith Albert Vernon, Bartz Traci M, Feitosa Mary F, Gao Wei, Ahluwalia Tarunveer S, Tang Wenbo, Oldmeadow Christopher, Duan Qing, de Jong Kim, Wojczynski Mary K, Wang Xin-Qun, Noordam Raymond, Hartwig Fernando Pires, Jackson Victoria E, Wang Tianyuan, Obeidat Ma'en, Hobbs Brian D, Huan Tianxiao, Gui Hongsheng, Parker Margaret M, Hu Donglei, Mogil Lauren S, Kichaev Gleb, Jin Jianping, Graff Mariaelisa, Harris Tamara B, Kalhan Ravi, Heckbert Susan R, Paternoster Lavinia, Burkart Kristin M, Liu Yongmei, Holliday Elizabeth G, Wilson James G, Vonk Judith M, Sanders Jason L, Barr R Graham, de Mutsert Renée, Menezes Ana Maria Baptista, Adams Hieab H H, van den Berge Maarten, Joehanes Roby, Levin Albert M, Liberto Jennifer, Launer Lenore J, Morrison Alanna C, Sitlani Colleen M, Celedón Juan C, Kritchevsky Stephen B, Scott Rodney J, Christensen Kaare, Rotter Jerome I, Bonten Tobias N, Wehrmeister Fernando César, Bossé Yohan, Xiao Shujie, Oh Sam, Franceschini Nora, Brody Jennifer A, Kaplan Robert C, Lohman Kurt, McEvoy Mark, Province Michael A, Rosendaal Frits R, Taylor Kent D, Nickle David C, Williams L Keoki, Burchard Esteban G, Wheeler Heather E, Sin Don D, Gudnason Vilmundur, North Kari E, Fornage Myriam, Psaty Bruce M, Myers Richard H, O'Connor George, Hansen Torben, Laurie Cathy C, Cassano Patricia A, Sung Joohon, Kim Woo Jin, Attia John R, Lange Leslie, Boezen H Marike, Thyagarajan Bharat, Rich Stephen S, Mook-Kanamori Dennis O, Horta Bernardo Lessa, Uitterlinden André G, Im Hae Kyung, Cho Michael H, Brusselle Guy G, Gharib Sina A, Dupuis Josée, Manichaikul Ani, London Stephanie J. Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.. Nature communications. 2018. DOI: 10.1038/s41467-018-05369-0.
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