[Many-year course of systemic lupus erythematosus with cerebral symptoms].

During 20 years of disease duration in the reported woman aged 47 years at the time of death articular involvement was followed by cardiac involvement and after labour renal signs appeared. Cerebral signs developed about 11 years before her death and manifested themselves as several typical strokes. The observed systemic affections, including the neurological signs, responded favourably to immunosuppression. Postmortem examination of the brain demonstrated numerous ischaemic foci, including a large cerebellar infarction, due to proliferative changes in the walls of cerebral and meningeal vessels.