The American journal of gastroenterology · 2025
TRENDS IN THE ULCERATIVE COLITIS TO CROHN'S DISEASE INCIDENCE RATIO ARE DISTINCT BETWEEN EPIDEMIOLOGIC STAGES OF INFLAMMATORY BOWEL DISEASE.
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Windsor Joseph W, Coward Stephanie, Hracs Lindsay, Mak Joyce W Y, Banerjee Rupa, Kotze Paulo G, Gearry Richard, Ng Siew C, Kaplan Gilaad G, Global IBD Visualization of Epidemiology Studies in the 21s,t Century (GIVES-21) Research Group
Аннотация
INTRODUCTION: The ulcerative colitis (UC) to Crohn's disease (CD) incidence ratio varies across geography and time.
METHODS: We analyzed UC:CD incidence ratios across three epidemiologic stages using generalized additive models for location, shape, and scale and pooled average annual percent changes (AAPCs) by meta-analysis.
RESULTS: Ratios significantly decreased: median 3.62 in stage 1, 1.82 in stage 2, 1.55 in stage 3; the incidence ratio stabilized in stage 3 (AAPC: -0.12; 95%CI: -0.66, 0.42).
DISCUSSION: Decreasing UC:CD incidence ratios signal a rising burden of CD, underscoring the need to anticipate greater healthcare demand, including higher treatment costs and higher prevalence of complications.
METHODS: We analyzed UC:CD incidence ratios across three epidemiologic stages using generalized additive models for location, shape, and scale and pooled average annual percent changes (AAPCs) by meta-analysis.
RESULTS: Ratios significantly decreased: median 3.62 in stage 1, 1.82 in stage 2, 1.55 in stage 3; the incidence ratio stabilized in stage 3 (AAPC: -0.12; 95%CI: -0.66, 0.42).
DISCUSSION: Decreasing UC:CD incidence ratios signal a rising burden of CD, underscoring the need to anticipate greater healthcare demand, including higher treatment costs and higher prevalence of complications.