Future microbiology · 2024
Anticandidal activity of Croton heliotropiifolius Kunth essential oil is enhanced by N-acetylcysteine and itraconazole.
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Cavalcanti Bruno Coêlho, Magalhães Islay Lima, Rodrigues Daniel Sampaio, Cabral Vitória Pessoa de Farias, Barbosa Amanda Dias, Valente Sá Lívia Gurgel do Amaral, da Silva Lisandra Juvêncio, de Andrade Neto João Batista, da Silva Cecília Rocha, de Moraes Manoel Odorico, Dos Santos Cláudio Costa, Nobre Júnior Hélio Vitoriano
Аннотация
Aim: Evaluate the anticandidal effect of Croton heliotropiifolius Kunth essential oil and its interaction with azoles and N-acetylcysteine (NAC) against planktonic cells and biofilms.Materials & methods: Broth microdilution and checkerboard methods were used to evaluate the individual and combined activity with fluconazole and itraconazole (ITRA). The antibiofilm effect of the oil was assessed in 96-well plates alone and combined with ITRA and NAC, and cytotoxicity determined by MTT.Results: The oil inhibited all Candida species growth. The activity was enhanced when associated with ITRA and NAC for planktonic cells and biofilms in formation. The effective concentrations were lower than the toxic ones to V79 cells.Conclusion: C. heliotropiifolius Kunth essential oil is an anticandidal alternative, and can be associated with ITRA and NAC.