Ophthalmic surgery, lasers & imaging retina · 2026
Comparative Study of Swept-source Optical Coherence Tomography Angiography Metrics Between Eyes With Adult Onset Vitelliform Dystrophy, Age-related Macular Degeneration, and Healthy Controls.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Whang Ken, Garg Itika, Harel Iris Deitch, Katz Raviv, Cui Ying, Zeng Rebecca, Duich Margaret, Wescott Hannah E, Koch Thomas, Bannerman Augustine, Baldwin Grace, Nigalye Archana, Lains Ines, Eliott Dean, Patel Nimesh A, Kim Leo A, Vavvas Demetrios G, Miller Joan W, Hussain Deeba, Miller John B
Аннотация
BACKGROUND AND OBJECTIVE: The aim of this study was to investigate swept-source OCT angiography (SSOCTA) metrics in adult-onset foveovitelliform dystrophy (AOFVD), intermediate age-related macular degeneration (iAMD), and healthy control eyes.
PATIENTS AND METHODS: A cross-sectional study analyzing SS-OCTA foveal avascular zone (FAZ), vessel skeletonized density (VSD), and vessel density (VD) using the ARI network was conducted. A mixed-effects multiple regression model adjusting for age was used for statistical analyses.
RESULTS: The cohort included 204 eyes of 125 patients (control, n = 63; iAMD, n = 93; AOFVD, n = 48). Compared to iAMD, AOFVD eyes had significantly reduced VD, VSD, and FAZ circularity on 3 × 3-mm and 6 × 6-mm angiograms, and significantly increased FAZ area and FAZ perimeter on 6 × 6-mm angiograms. There was no difference on 12 × 12-mm angiograms. Compared to controls, AOFVD eyes had significantly reduced FAZ circularity on 3 × 3-mm angiograms.
CONCLUSION: SS-OCTA metrics may help in distinguishing AOFVD from iAMD.
PATIENTS AND METHODS: A cross-sectional study analyzing SS-OCTA foveal avascular zone (FAZ), vessel skeletonized density (VSD), and vessel density (VD) using the ARI network was conducted. A mixed-effects multiple regression model adjusting for age was used for statistical analyses.
RESULTS: The cohort included 204 eyes of 125 patients (control, n = 63; iAMD, n = 93; AOFVD, n = 48). Compared to iAMD, AOFVD eyes had significantly reduced VD, VSD, and FAZ circularity on 3 × 3-mm and 6 × 6-mm angiograms, and significantly increased FAZ area and FAZ perimeter on 6 × 6-mm angiograms. There was no difference on 12 × 12-mm angiograms. Compared to controls, AOFVD eyes had significantly reduced FAZ circularity on 3 × 3-mm angiograms.
CONCLUSION: SS-OCTA metrics may help in distinguishing AOFVD from iAMD.