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RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin · 1995

[Bronchiectasis and infection incidence in alpha 1-antitrypsin deficiency. The value of high-resolution computed tomography].

Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Kauczor H U, Hoffmann A, Mehdikhani H, Schunk K, Schlegel J, Mildenberger P

Аннотация

UNLABELLED: PURPOSE of this study was to determine the prevalence of bronchiectasis in patients suffering from alpha-1-antitrypsin deficiency and to compare its extent with the frequency of infections.

MATERIAL AND METHODS: High-resolution CT examinations (HRCT) of 23 patients with alpha-1-antitrypsin deficiency were retrospectively assessed for extent, severity and localisation of bronchiectasis, bronchial wall thickening and extent of emphysema. Chest radiographs and clinical records were available for correlation.

RESULTS: HRCT scans showed bronchiectasis in 14 of 23 patients, bronchial wall thickening in 3/14, and panlobular emphysema in 23/23. Chest radiographs showed bronchiectasis in 4/23 patients. Only two of 9 patients without bronchiectasis had a history of infections; all 8 patients with multiple bronchiectasis had a history of recurrent infections.

CONCLUSION: Bronchiectasis is a common finding in alpha-1-antitrypsin deficiency, and is associated with recurrent infections. HRCT is superior to chest radiography as an indicator for the risk of infection in these patients.

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