Comparative evaluation of platelet-rich fibrin and collagen membrane for guided bone regeneration in alveolar defects.

Alveolar bone defects following tooth loss, trauma, or pathology compromise implant placement and prosthetic rehabilitation, necessitating effective guided bone regeneration strategies. Therefore, it is of interest to compare the clinical and radiographic outcomes of platelet-rich fibrin (PRF) and resorbable collagen membranes in alveolar defect regeneration. Hence, forty patients were randomly allocated into PRF (n=20) and collagen membrane (n=20) groups, both combined with particulate bone graft, with evaluation of healing parameters and CBCT-based bone gain at baseline and 6 months. Both groups demonstrated significant bone regeneration, with slightly greater horizontal gain in the collagen group, while vertical gain and complication rates showed no statistically significant differences. PRF and collagen membranes exhibit comparable regenerative efficacy, with PRF offering additional advantages of autologous origin, cost-effectiveness, and enhanced soft tissue healing.