Advances in celiac disease.

PURPOSE OF REVIEW: This article aims to summarize recent critical research in celiac disease.

RECENT FINDINGS: The crucial epitopes that confer toxicity to gliadin and related prolamins continue to be defined, as do methods of assessing their toxicity. New approaches to making the gluten-free diet more palatable are being studied.

SUMMARY: The position of proline residues is critical to the toxicity of cereal proteins to patients with celiac disease. Other genetic factors, apart from HLA status, remain elusive. Exciting advances in altering the toxicity of cereal proteins are being made.