Serum phosphate increase during short-term beta-adrenoceptor blockade in thyrotoxicosis.

We studied the changes in blood plasma electrolytes during acute and short-term treatment with four different beta-adrenergic-blocking agents in 31 patients with hyperthyroidism. Serum phosphate increased during the first four hours and remained elevated after one week both after cardioselective (acebutolol) and non-cardioselective (oxprenolol, pindolol and timolol) beta-blockade (p less than 0.05). Albumin decreased after four hours but no change was found after one week. Serum creatinine increased after one week in the acebutolol-treated group, while sodium, potassium and albumin-corrected calcium in serum did not change. The hyperphosphatemic effect may be due to blockade of beta 1-adrenoceptors, since the effect of the cardioselective acebutolol was no less than that of the non-cardioselective beta-adrenoceptor blockers.