Медицинская библиотека · Clinical and experimental dermatology · 2019

Abnormal expression of the co-stimulatory molecule B7-H3 in lichen simplex chronicus is associated with expansion of Langerhans cells.

Feng X, Yang M, Yang Z, Qian Q, Burns E M, Min W

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Аннотация

BACKGROUND

The co-stimulatory molecule B7-H3, a cell surface transmembrane glycoprotein, was assessed for its functional and prognostic role in lichen simplex chronicus (LSC).

AIM: To investigate if abnormal expression of the co-stimulatory molecule B7-H3 in LSC is associated with Langerhans cell (LC) expansion.

METHODS

We used immunohistochemistry to stain LSC skin tissue, and evaluated if the immunostaining of B7-H3 and interleukin (IL)-6 was significantly different.

RESULTS

Our results indicated that B7-H3 is abnormally expressed in LSC skin tissue and positively regulates LC expansion. We also found that IL-6 might modulate B7-H3 expression. Moreover, LC expansion in LSC leads to the proliferation of T cells.

CONCLUSIONS

Our study indicates the potential value of immunotherapy as a treatment for LSC.

Для цитирования: Feng X, Yang M, Yang Z, Qian Q, Burns E M, Min W. Abnormal expression of the co-stimulatory molecule B7-H3 in lichen simplex chronicus is associated with expansion of Langerhans cells.. Clinical and experimental dermatology. 2019. DOI: 10.1111/ced.14001.

Предметные рубрики MeSH

Adolescent Adult Aged Animals B7 Antigens Female Humans Interleukin-6 Langerhans Cells Male Mice Middle Aged Neurodermatitis Skin Young Adult

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