Vagal nerve stimulation for treatment-resistant depression: An update on mechanism of action and clinical use.

Among few available therapeutic options for patients with treatment-resistant depression, chronic stimulation of the vagus nerve using an implanted stimulator, the so-called vagal nerve stimulation (VNS), has been shown to be both effective and safe technique, based on the multitude of studies. While the exact degree of its efficacy remains a subject of discussion, the strong scientific basis and a large body of data from completed and ongoing clinical trials suggest that VNS remains a viable option for those patients, who have exhausted less invasive treatment approaches.