Frontiers in oncology · 2026
Multicenter clinical application of regulatory dual-channel digestive tract reconstruction with pylorus-preserving approach in advanced gastric cancer.
Клиническое исследованиеСтатьяНазвание и аннотация: Перевод в очереди
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Zhou Hangyu, Li Ranmiao, Chen Jin, Ming Rui, Yang Yu, Zhou Guomin, Jiang Huaiwu
Аннотация
BACKGROUND: To evaluate the clinical significance of regulatory dual-channel digestive tract reconstruction with a pylorus-preserving approach in advanced gastric cancer through a multicenter study.
METHODS: A total of 137 gastric cancer patients who underwent radical gastrectomy at three hospitals in Mianyang, China, between March 2018 and March 2023 were included. Patients were divided into a study group (n=68) undergoing regulatory dual-channel reconstruction with pylorus preservation and a control group (n=69) receiving total gastrectomy with Roux-en-Y reconstruction. Operative time, intraoperative blood loss, postoperative complications, and quality of life were compared.
RESULTS: No significant differences were found between the groups regarding demographic and clinical characteristics, operative time, intraoperative blood loss, gastrointestinal function recovery, or hospital stay (P>0.05). Postoperative complications, including pulmonary infections, anastomotic leakage, gastrointestinal bleeding, and reflux esophagitis, also showed no significant differences (P>0.05). However, dumping syndrome was significantly less frequent in the study group (P<0.05). Both groups showed improvement in functional status and overall health from 1 to 24 months postoperatively. The study group had significantly higher physical function scores at 24 months (P<0.05), along with better emotional function and overall health scores from 6 to 24 months (P<0.05). Additionally, diarrhea scores were significantly lower in the study group at 1 and 6 months (P<0.05), while other functional and symptom domains showed no differences (P>0.05).
CONCLUSION: Regulatory dual-channel digestive tract reconstruction with pylorus preservation is a safe and effective approach that improves postoperative quality of life in patients with advanced gastric cancer.
SYNOPSIS: Pylorus-preserving dual-channel reconstruction in advanced gastric cancer improves quality of life, reduces dumping syndrome, and shows comparable safety to total gastrectomy with Roux-en-Y.
METHODS: A total of 137 gastric cancer patients who underwent radical gastrectomy at three hospitals in Mianyang, China, between March 2018 and March 2023 were included. Patients were divided into a study group (n=68) undergoing regulatory dual-channel reconstruction with pylorus preservation and a control group (n=69) receiving total gastrectomy with Roux-en-Y reconstruction. Operative time, intraoperative blood loss, postoperative complications, and quality of life were compared.
RESULTS: No significant differences were found between the groups regarding demographic and clinical characteristics, operative time, intraoperative blood loss, gastrointestinal function recovery, or hospital stay (P>0.05). Postoperative complications, including pulmonary infections, anastomotic leakage, gastrointestinal bleeding, and reflux esophagitis, also showed no significant differences (P>0.05). However, dumping syndrome was significantly less frequent in the study group (P<0.05). Both groups showed improvement in functional status and overall health from 1 to 24 months postoperatively. The study group had significantly higher physical function scores at 24 months (P<0.05), along with better emotional function and overall health scores from 6 to 24 months (P<0.05). Additionally, diarrhea scores were significantly lower in the study group at 1 and 6 months (P<0.05), while other functional and symptom domains showed no differences (P>0.05).
CONCLUSION: Regulatory dual-channel digestive tract reconstruction with pylorus preservation is a safe and effective approach that improves postoperative quality of life in patients with advanced gastric cancer.
SYNOPSIS: Pylorus-preserving dual-channel reconstruction in advanced gastric cancer improves quality of life, reduces dumping syndrome, and shows comparable safety to total gastrectomy with Roux-en-Y.