Journal of Nippon Medical School = Nippon Ika Daigaku zasshi · 2026
Pregnancy Transiently Normalized Platelet Counts in Essential Thrombocytosis.
СтатьяНазвание и аннотация: Перевод в очереди
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Homma Shunsuke, Wakita Satoshi, Sakaguchi Masahiro, Yui Shunsuke, Inokuchi Koiti, Yamaguchi Hiroki
Аннотация
BACKGROUND: Outcomes of pregnancies complicated by essential thrombocytosis (ET) are worse than those of normal pregnancies. Aspirin, heparin, and interferon (IFN)-α are well-tolerated during pregnancy and prescribed in accordance with the risk of thrombosis. However, some evidence suggests that platelet count decreases during ET-complicated pregnancies.
METHODS: We retrospectively analyzed changes in platelet count in ET-complicated pregnancies.
RESULTS: Platelet count decreased during pregnancy without IFN-α use, and 83% of pregnant women had a platelet count of ≤450×109/L. Furthermore, all pregnant women achieved a platelet count of ≤600×109/L. One the basis of revised IPSET-thrombosis score, risk was classified as low or very low. Aspirin use starting in early pregnancy was associated with a higher rate of successful delivery, even in patients with prior miscarriage.
CONCLUSIONS: These findings suggest that platelet counts decrease in selected low-risk and very-low-risk ET-complicated pregnancies and that cytoreductive therapy with IFN-α may be avoidable in some cases. These results should be interpreted cautiously because of the small sample size and retrospective study design.
METHODS: We retrospectively analyzed changes in platelet count in ET-complicated pregnancies.
RESULTS: Platelet count decreased during pregnancy without IFN-α use, and 83% of pregnant women had a platelet count of ≤450×109/L. Furthermore, all pregnant women achieved a platelet count of ≤600×109/L. One the basis of revised IPSET-thrombosis score, risk was classified as low or very low. Aspirin use starting in early pregnancy was associated with a higher rate of successful delivery, even in patients with prior miscarriage.
CONCLUSIONS: These findings suggest that platelet counts decrease in selected low-risk and very-low-risk ET-complicated pregnancies and that cytoreductive therapy with IFN-α may be avoidable in some cases. These results should be interpreted cautiously because of the small sample size and retrospective study design.