MitraClip in Patients With Mitral Regurgitation and Left Ventricular Ejection Fraction <30%　- Potential Implications for the Treatment of Patients in Japan.

BACKGROUND

The effect of the unique Japanese indication for MitraClip based on left ventricular ejection fraction (LVEF) is unclear.

METHODS AND

RESULTS

We analyzed 874 patients who underwent MitraClip because of mitral regurgitation (MR) and compared the characteristics and outcomes between patients with LVEF <30% and ≥30%. Patients with LVEF ≤30% accounted for 33% of the study population and had a higher prevalence of functional MR. Severity of MR after MitraClip was comparable, and LVEF <30% did not independently affect survival.

CONCLUSIONS

Japanese unique indication based on LVEF may exclude one third of patients who were treated with MitraClip in Europe.