World journal of gastroenterology · 2016
Prognostic value of pre-treatment F-18-FDG PET-CT in patients with hepatocellular carcinoma undergoing radioembolization.
Оценочное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Abuodeh Yazan, Naghavi Arash O, Ahmed Kamran A, Venkat Puja S, Kim Youngchul, Kis Bela, Choi Junsung, Biebel Benjamin, Sweeney Jennifer, Anaya Daniel A, Kim Richard, Malafa Mokenge, Frakes Jessica M, Hoffe Sarah E, El-Haddad Ghassan
Аннотация
AIM: To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver radioembolization.
METHODS: We identified 34 patients with HCC who underwent an FDG PET/CT scan prior to hepatic radioembolization at our institution between 2009 and 2013. Patients were seen in clinic one month after radioembolization and then at 2-3 mo intervals. We assessed the influence of FDG tumor uptake on outcomes including local liver control (LLC), distant liver control (DLC), time to distant metastases (DM), progression free survival (PFS) and overall survival (OS).
RESULTS: The majority of patients were males (n = 25, 74%), and had Child Pugh Class A (n = 31, 91%), with a median age of 68 years (46-84 years). FDG-avid disease was found in 19 (56%) patients with SUVmax ranging from 3 to 20. Female patients were more likely to have an FDG-avid HCC (P = 0.02). Median follow up of patients following radioembolization was 12 months (1.2-62.8 mo). FDG-avid disease was associated with a decreased 1 year LLC, DLC, DM and PFS (P < 0.05). Using multivariate analysis, FDG avidity predicted for LLC, DLC, and PFS (all P < 0.05).
CONCLUSION: In this retrospective study, pre-treatment HCC FDG-avidity was found to be associated with worse LLC, DLC, and PFS following radioembolization. Larger studies are needed to validate our initial findings to assess the role of F-18-FDG PET/CT scans as biomarker for patients with HCC following radioembolization.
METHODS: We identified 34 patients with HCC who underwent an FDG PET/CT scan prior to hepatic radioembolization at our institution between 2009 and 2013. Patients were seen in clinic one month after radioembolization and then at 2-3 mo intervals. We assessed the influence of FDG tumor uptake on outcomes including local liver control (LLC), distant liver control (DLC), time to distant metastases (DM), progression free survival (PFS) and overall survival (OS).
RESULTS: The majority of patients were males (n = 25, 74%), and had Child Pugh Class A (n = 31, 91%), with a median age of 68 years (46-84 years). FDG-avid disease was found in 19 (56%) patients with SUVmax ranging from 3 to 20. Female patients were more likely to have an FDG-avid HCC (P = 0.02). Median follow up of patients following radioembolization was 12 months (1.2-62.8 mo). FDG-avid disease was associated with a decreased 1 year LLC, DLC, DM and PFS (P < 0.05). Using multivariate analysis, FDG avidity predicted for LLC, DLC, and PFS (all P < 0.05).
CONCLUSION: In this retrospective study, pre-treatment HCC FDG-avidity was found to be associated with worse LLC, DLC, and PFS following radioembolization. Larger studies are needed to validate our initial findings to assess the role of F-18-FDG PET/CT scans as biomarker for patients with HCC following radioembolization.
Предметные рубрики MeSH
AgedAged, 80 and overCarcinoma, HepatocellularChi-Square DistributionDisease ProgressionDisease-Free SurvivalEmbolization, TherapeuticFemaleFloridaFluorodeoxyglucose F18HumansKaplan-Meier EstimateLiver NeoplasmsMaleMicrospheresMiddle AgedMultivariate AnalysisNeoplasm Recurrence, LocalPositron Emission Tomography Computed TomographyPredictive Value of TestsProportional Hazards ModelsRadiopharmaceuticalsRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeYttrium Radioisotopes