Comparative distribution of eosinophils in bone marrow, blood and peritoneal cavity in murine schistosomiasis.

Eosinophilia in murine schistosomiasis is very intense and extensive, involving distinct compartments such as bone marrow, blood, peritoneal cavity and tissues. Comparison of the shapes of eosinophil concentration or distribution curves showed a synchronization of the tendencies around 50% between blood and bone marrow, 33 to 64% between blood and peritoneal cavity, and 33 to 43% between peritoneal cavity and bone marrow. The hepatic eosinophil granulocytopoiesis or metaplasia follows the same pattern as observed in bone marrow. Schistosoma infection can be divided into three distinct phases based on the eosinophilic response: 1) non- or low-productive phase (before 35-40 days of infection), 2) acute productive phase (from 35-40 to 70-90 days), and 3) chronic productive phase (after 70-90 days of infection).