Biomarkers in medicine · 2026
Insulin resistance‑associated adipokine and oxidative stress profiles in women with polycystic ovary syndrome.
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Muwafaq Saleem Hiba, Al-Hetty Hussein Riyadh Abdul Kareem, Rasheed Hanan Yousif, Mohammed Ruaa Abdulazez
Аннотация
BACKGROUND: Although polycystic ovary syndrome (PCOS) is an endocrine and metabolic disorder among reproductive-aged women, the integrated role of adipokines in linking metabolic and hormonal dysfunction remains incompletely understood.
OBJECTIVE: The study aims to evaluate the associations between lipid profile alterations, selected adipokines (resistin, galectin-3, and apelin), oxidative stress markers, and the insulin resistance index (HOMA-IR) in women with PCOS compared to controls.
METHODS: This case-control study included 85 women with PCOS and 55 age-matched controls. Anthropometric and clinical data were collected. Levels of lipid profiles, adipokines, oxidative stress markers, and HOMA-IR were measured. Group comparisons and correlation analyses were performed.
RESULTS: Women with PCOS demonstrated elevated levels of resistin, galectin-3, and apelin compared to the controls, with respective measurements of 3.55 ± 0.52 vs 1.07 ± 0.34, 10.01 ± 1.76 vs 3.49 ± 1.03, and 289.23 ± 20.08 vs 191.31 ± 31.30), respectively. MDA exhibited a significant increase, whereas TAC was significantly reduced in the PCOS group. HOMA-IR showed significant positive associations with lipid profiles, adipokines, and levels of MDA, and an inverse correlation with HDL and TAC.
CONCLUSION: The findings support the concept that altered adipokine levels and oxidative stress indices may reflect underlying metabolic dysfunction in women with PCOS.
OBJECTIVE: The study aims to evaluate the associations between lipid profile alterations, selected adipokines (resistin, galectin-3, and apelin), oxidative stress markers, and the insulin resistance index (HOMA-IR) in women with PCOS compared to controls.
METHODS: This case-control study included 85 women with PCOS and 55 age-matched controls. Anthropometric and clinical data were collected. Levels of lipid profiles, adipokines, oxidative stress markers, and HOMA-IR were measured. Group comparisons and correlation analyses were performed.
RESULTS: Women with PCOS demonstrated elevated levels of resistin, galectin-3, and apelin compared to the controls, with respective measurements of 3.55 ± 0.52 vs 1.07 ± 0.34, 10.01 ± 1.76 vs 3.49 ± 1.03, and 289.23 ± 20.08 vs 191.31 ± 31.30), respectively. MDA exhibited a significant increase, whereas TAC was significantly reduced in the PCOS group. HOMA-IR showed significant positive associations with lipid profiles, adipokines, and levels of MDA, and an inverse correlation with HDL and TAC.
CONCLUSION: The findings support the concept that altered adipokine levels and oxidative stress indices may reflect underlying metabolic dysfunction in women with PCOS.