Discovery of small molecule ACC inhibitors: Potential treatment for excessive sebum secretion.

Overproduction of sebum can lead to various skin disorders, including acne and seborrheic dermatitis. Acetyl-CoA carboxylase is a key enzyme in the de novo synthesis of sebum. Consequently, inhibiting acetyl-CoA carboxylase is a feasible strategy to reduce sebum production, thereby providing therapeutic benefits for associated skin conditions. This review described the de novo synthesis of sebum and discusseed the various isoforms, functions and catalytic mechanisms of acetyl-CoA carboxylase. Additionally, it offered a comprehensive overview of the research advancements and structural-activity relationships of small molecule inhibitors of acetyl-CoA carboxylase over the past 15 years.