Retina (Philadelphia, Pa.) · 2026
PIGMENT EPITHELIUM DETACHMENT IN SEVERE ACUTE POSTERIOR MULTIFOCAL PLACOID PIGMENT EPITHELIOPATHY.
СтатьяМногоцентровое исследованиеНаблюдательное исследованиеНазвание и аннотация: Перевод в очереди
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Dentel Alexandre, Widehen Chloé, Goupillou Paul, Hoogewoud Florence, Mrejen Sarah, Fardeau Christine, Titah Cherif, Gargouri Mohamed A, Couturier Aude, Gaudric Alain, Bousquet Elodie
Аннотация
PURPOSE: To describe the spectrum of optical coherence tomography (OCT) findings in acute posterior multifocal placoid pigment epitheliopathy (APMPPE), with a specific focus on the prevalence of pigment epithelium detachments (PEDs).
METHODS: Multicenter, retrospective, longitudinal study including patients diagnosed with APMPPE based on color fundus photography, OCT, and fluorescein angiography. Demographics, visual acuity, and the following OCT findings were assessed: outer retinal hyperreflectivity, serous retinal detachment (SRD), bacillary layer detachment (BALAD), and PED.
RESULTS: Forty-six eyes of 27 patients were included. The median age at presentation was 23 years (range: 18-36 years), and 17 patients (62.9%) were men. At baseline, outer retinal hyperreflectivity was found in all eyes, while BALAD, SRD, and PED were observed in 22 (47.8%), 14 (30.4%), and 26 eyes (56.5%), respectively. A univariate logistic regression showed a significant association between the presence of PED and a worse baseline visual acuity (odds ratio [OR]: 5.3; 95% confidence interval [CI]: 1.5-18.6; P = 0.01), the presence of BALAD (OR: 9.0; 95% CI: 2.3-35.6; P = 0.002), and the presence of SRD (OR: 7.3; 95% CI: 1.4-38.3; P = 0.02).
CONCLUSION: PEDs were significantly associated with a poorer initial visual acuity, as well as with the presence of BALAD and SRD on presentation. These findings suggest that PEDs could be used as a biomarker of disease severity and choriocapillaris ischemia in APMPPE.
METHODS: Multicenter, retrospective, longitudinal study including patients diagnosed with APMPPE based on color fundus photography, OCT, and fluorescein angiography. Demographics, visual acuity, and the following OCT findings were assessed: outer retinal hyperreflectivity, serous retinal detachment (SRD), bacillary layer detachment (BALAD), and PED.
RESULTS: Forty-six eyes of 27 patients were included. The median age at presentation was 23 years (range: 18-36 years), and 17 patients (62.9%) were men. At baseline, outer retinal hyperreflectivity was found in all eyes, while BALAD, SRD, and PED were observed in 22 (47.8%), 14 (30.4%), and 26 eyes (56.5%), respectively. A univariate logistic regression showed a significant association between the presence of PED and a worse baseline visual acuity (odds ratio [OR]: 5.3; 95% confidence interval [CI]: 1.5-18.6; P = 0.01), the presence of BALAD (OR: 9.0; 95% CI: 2.3-35.6; P = 0.002), and the presence of SRD (OR: 7.3; 95% CI: 1.4-38.3; P = 0.02).
CONCLUSION: PEDs were significantly associated with a poorer initial visual acuity, as well as with the presence of BALAD and SRD on presentation. These findings suggest that PEDs could be used as a biomarker of disease severity and choriocapillaris ischemia in APMPPE.