Annals of neurology · 2025
Elevated α-Synuclein Aggregate Levels in the Urine of Patients with Isolated REM Sleep Behavior Disorder and Parkinson's Disease.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Müller Laura, Özdüzenciler Pelin, Schedlich-Teufer Charlotte, Seger Aline, Jergas Hannah, Fink Gereon R, Willbold Dieter, Sommerauer Michael, Barbe Michael T, Tamgüney Gültekin
Аннотация
Parkinson's disease (PD) is a neurodegenerative disorder characterized by α-synuclein aggregation in neurons. Recent advances suggest α-synuclein aggregates could serve as a biomarker for PD and related synucleinopathies. This study used surface-based fluorescence intensity distribution analysis (sFIDA) to measure α-synuclein aggregates in urine. Patients with PD and isolated rapid eye movement sleep behavior disorder, a precursor to PD, had elevated concentrations compared with healthy controls. Sensitivity and specificity were 83% and 65% for PD versus controls and 89% and 62% for isolated rapid eye movement sleep behavior disorder versus controls. The findings highlight sFIDA's potential for diagnosing synucleinopathies. ANN NEUROL 2025;98:147-151.