Investigating Dopamine Replacement-Associated Fluctuations in Cognition and Mood in Cognitively Unimpaired Parkinson's Disease.

BACKGROUND

Non-motor fluctuations, characterized by variability in mood and cognition, are prevalent in advanced Parkinson's disease (PD), but less is known about these fluctuations in early PD.

OBJECTIVE

The objective was to characterize fluctuations in cognition and mood in early PD without cognitive impairment.

METHODS

Individuals with PD but without cognitive impairment were evaluated "on" and "off" dopaminergic medications for minimal clinically important differences (MCID) in depression, anxiety, and cognition. Multivariable logistic regression evaluated factors associated with medication-related fluctuations in anxiety, depression, and cognition.

RESULTS

Clinically meaningful fluctuations in anxiety were associated with dysautonomia (OR [odds ratio] 7.5) and female sex (OR 3.9). Fluctuations in Symbol Digit Modalities Test (SDMT), a measure of processing speed and executive function, were associated with dysautonomia (OR 2.82). Such an association was not found with depression or Stroop test.

CONCLUSIONS

Dysautonomia may influence fluctuations in anxiety and some aspects of cognition in cognitively unimpaired PD.