Journal of medical primatology · 2026
Comparison of Laser Doppler Flowmetry With Contrast-Enhanced Ultrasound to Approximate Placental Microvascular Blood Flow in the African Green Monkey (Chlorocebus aethiops sabaeus).
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Gonzalez-Rodriguez Yarines, Walmer Rachel W, Krainiak Shannon, Carter Kelli, Kavanagh Kylie, Johnson Kennita, Cilvik Sarah N
Аннотация
BACKGROUND: The ability to study in vivo microvascular flow within the placenta is limited. We sought to compare two techniques for evaluation of placental perfusion in a translational nonhuman primate model.
METHODS: We measured placental microvascular perfusion in six pregnant African green monkeys (Chlorocebus aethiops sabaeus) using both Laser Doppler Flowmetry (LDF) and contrast-enhanced ultrasound (CEUS) in 2-4 discrete placental locations per animal at early- (EG), mid- (MG), and/or late-gestation (LG). We assessed correlation between matched LDF and CEUS, with the hypothesis that we would observe concordance between these two measures of relative perfusion.
RESULTS: Using 35 total paired measurements (13 EG, n = 4; 12 MG, n = 4; 10 LG, n = 5), we found no correlation between LDF microvascular perfusion and CEUS microvascular flux rate (Pearson r = -0.2026, R2 = 0.0411, p = 0.2431).
CONCLUSION: LDF and CEUS produce discordant results with respect to placental perfusion. LDF is ill-suited to a heterogeneous organ such as the placenta.
METHODS: We measured placental microvascular perfusion in six pregnant African green monkeys (Chlorocebus aethiops sabaeus) using both Laser Doppler Flowmetry (LDF) and contrast-enhanced ultrasound (CEUS) in 2-4 discrete placental locations per animal at early- (EG), mid- (MG), and/or late-gestation (LG). We assessed correlation between matched LDF and CEUS, with the hypothesis that we would observe concordance between these two measures of relative perfusion.
RESULTS: Using 35 total paired measurements (13 EG, n = 4; 12 MG, n = 4; 10 LG, n = 5), we found no correlation between LDF microvascular perfusion and CEUS microvascular flux rate (Pearson r = -0.2026, R2 = 0.0411, p = 0.2431).
CONCLUSION: LDF and CEUS produce discordant results with respect to placental perfusion. LDF is ill-suited to a heterogeneous organ such as the placenta.