Parkinsonism & related disorders · 2025
Clinical and electrophysiological characteristics of large and small fiber neuropathy in Parkinson's disease.
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Xie Chunge, Gan Rong, Chen Jieling, Li Yanyi, He Peikun, Gao Yuyuan, Wang Limin, Ma Guixian, Zhang Yuhu, Nie Kun, Wang Lijuan
Аннотация
PURPOSE: The study aims to assess clinical data and peripheral nerve function in Parkinson's disease (PD) patients to explore the characteristics and risk factors of different peripheral neuropathies. Using Propensity Score Matching (PSM) to control confounders, it also examines the impact of oral levodopa on neuropathy incidence.
METHODS: 117 PD patients were recruited from Guangdong Provincial People's Hospital. Detailed demographic and clinical data were systematically collected, both large and small fiber nerve functions were evaluated. Based on the results of the peripheral nerve assessments, patients were categorized into different groups to analyze the risk factors associated with different types of peripheral damage. PSM was utilized to control potential confounding variables (such as age, disease duration), to examinate the impact of oral levodopa on neuropathy.
RESULTS: 55.56 % of the 117 PD patient exhibited peripheral neuropathy (PD-PN), including 22 (18.8 %) with large fiber damage, 29 (24.79 %) with small fiber damage, and 14 (11.97 %) exhibiting both large and small fiber damage. Higher UPDRSIII scores (OR 1.048, 95 %CI 1.015-1.082, p = 0.004) and advanced age (OR 1.068, 95 %CI 1.007-1.133, p = 0.029) were independent risk factors for peripheral neuropathy. There was no significant difference in the incidence of peripheral neuropathy between PD patients receiving oral levodopa treatment and those not receiving.
CONCLUSIONS: Our findings suggest that both large fiber and small fiber neuropathy are prevalent among PD patients. Higher UPDRSIII scores and advanced age are independent risk factors for different types of neuropathies. It is important to screening for peripheral neuropathy in PD patients.
METHODS: 117 PD patients were recruited from Guangdong Provincial People's Hospital. Detailed demographic and clinical data were systematically collected, both large and small fiber nerve functions were evaluated. Based on the results of the peripheral nerve assessments, patients were categorized into different groups to analyze the risk factors associated with different types of peripheral damage. PSM was utilized to control potential confounding variables (such as age, disease duration), to examinate the impact of oral levodopa on neuropathy.
RESULTS: 55.56 % of the 117 PD patient exhibited peripheral neuropathy (PD-PN), including 22 (18.8 %) with large fiber damage, 29 (24.79 %) with small fiber damage, and 14 (11.97 %) exhibiting both large and small fiber damage. Higher UPDRSIII scores (OR 1.048, 95 %CI 1.015-1.082, p = 0.004) and advanced age (OR 1.068, 95 %CI 1.007-1.133, p = 0.029) were independent risk factors for peripheral neuropathy. There was no significant difference in the incidence of peripheral neuropathy between PD patients receiving oral levodopa treatment and those not receiving.
CONCLUSIONS: Our findings suggest that both large fiber and small fiber neuropathy are prevalent among PD patients. Higher UPDRSIII scores and advanced age are independent risk factors for different types of neuropathies. It is important to screening for peripheral neuropathy in PD patients.