Tpeak-Tend interval predicts VT inducibility in arrhythmogenic mitral valve prolapse syndrome.

BACKGROUND

Mitral valve prolapse (MVP) is commonly benign, but an arrhythmic phenotype (AMVP) with increased risk for sudden cardiac death has been described. A prolonged Tpeak-Tend interval has been association with increased arrhythmic risk in different clinical settings. The aim of this study was to investigate a possible correlation between prolonged Tpeak-Tend interval and ventricular tachycardia (VT) inducibility in MVP.

METHODS AND

RESULTS

Sixty-five patients fulfilling the EHRA criteria of AMVP syndrome underwent programmed ventricular stimulation between 2016 and 2024. Sustained polymorphic VT was induced in 19 patients (29.2%) and was significantly associated with prolonged Tpeak-Tend (100.5 ± 10.3 ms vs. 85.1 ± 9.9 ms, p = 0.002) and prolonged Tpeak-Tend/QTc (0.24 ± 0.03 vs. 0.2 ± 0.02, p = 0.004).

CONCLUSION

Prolonged Tpeak-Tend was associated with VT inducibility in patients with AMVP syndrome, suggesting its potential value as simple ECG-based marker for risk stratification. If Tpeak-Tend also correlates with clinical outcome should be investigated in prospective studies.