An improved thin-layer chromatographic method for urinary oligosaccharide screening.

A modified thin-layer chromatographic screening method is presented for the rapid diagnosis of glycoprotein storage disorders based upon excess oligosaccharide excretion. The system has been used successfully in the diagnosis of mannosidosis, GM1 gangliosidosis, mucolipidoses types I and III, aspartyl-glycosaminuria and fucosidosis.