Fibrinogen Degradation Products and Periodontitis: Deciphering the Connection.

INTRODUCTION

Fibrinogen degradation products (e.g. D-dimer) arise from digested fibrin clots and fibrinogen. Elevated concentrations accompany activation of coagulation and fibrinolysis and indicate chronic inflammatory diseases. D-Dimer tests are a quick, noninvasive method to rule out abnormal clotting. Periodontitis strongly affects the haemostatic system and evokes a procoagulant state. Correlation of chronic periodontitis with early indicators of disease (biomarkers) might be useful.

AIM: The aim of the study was to examine whether the plasma D-dimer concentration reflects the progression of chronic periodontitis and the beneficial effect of periodontal therapy.

MATERIALS AND

METHODS

Forty randomly selected subjects were divided into four groups, Group I: 10 healthy subjects, Group II: 10 with mild periodontitis, Group III: 10 with moderate periodontitis, Group IV: 10 with severe periodontitis. After thorough dental and periodontal examination, 3 mL of venous blood was collected for measurement of fibrinogen degradation products.

RESULTS

The patients with moderate and chronic periodontitis exhibited high concentrations of D-dimer (mean value 434.98-535.52 mcg/mL), whereas subjects with mild or no periodontitis exhibited values of 329.78-211.29 mcg/mL. Concentrations of D-dimer were significantly reduced after therapy of all classes of periodontitis.

CONCLUSION

Periodontal treatment can reduce amount of D-dimer in the plasma. A higher than normal concentration is observed in chronic periodontitis.