[Levels of IL-8,IL-10 in patients with chronic periodontitis and coronary heart disease].

PURPOSE: To detect the level of interleukin-8 (IL-8) and interleukin-10 (IL-10) in serum and gingival crevicular fluid in patients with chronic severe periodontitis (CP) and coronary heart disease (CHD) and investigate the relationship between CP and CHD.

METHODS

Thirty patients with CHD and CP(group A), twenty-five patients with only CP(group B) and thirty healthy controls (group C) were included in this study. Gingival crevicular fluid and serum IL-8, IL-10 levels were detected by ELISA. SPSS 11.5 software package was used for statistical analysis.

RESULTS

The periodontal indexes including bleeding on probing and probing depth were significantly different among the 3 groups. In group A and B, the level of IL-8 in gingival crevicular fluid and serum were significantly lower, whereas the IL-10 level was significantly higher, in comparison to those in group C (P<0.05).

CONCLUSIONS

IL-8 and IL-10 may be associated with the pathogenesis of periodontitis and CHD. There may be a relationship between CHD and CP.