Psychiatry research · 2025
Screening for depressive disorders: Validation of the Patient Health Questionnaire for Adolescents (PHQ-A) in a population-based multi-ethnic Asian sample.
СтатьяВалидационное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Sung Sharon C, Ang Felicia Jia Ler, Liu Xueqing, Chakraborty Bibhas, Wong John Chee Meng, Fung Daniel Shuen Sheng, Ong Say How, Tian Cheong Sing, Kom Dennis, Fee Victoria, Liang Shen, Lei Natalie Cheok Ling, Teoh Jie Yu, Yap Qai Ven, Du RuoChen, Yap Natalie Hui Jing, Wan Michelle Jing Si, Sachiman Muhammad Nabil Syukri Bin, Sii Nicholas En-Ping, Kroneman Leoniek M, Teng Jia Ying, Ng Tze Pin, Verhulst Frank
Аннотация
OBJECTIVE: To validate the Patient Health Questionnaire for Adolescents (PHQ-A) as a screening tool for depressive disorders in multi-ethnic Asian adolescents.
METHODS: 323 English-speaking Singaporean adolescents completed the PHQ-A, Kiddie Schedule for Affective Disorders and Schizophrenia Present and Lifetime Version (K-SADS-PL), and measures of depressive symptoms (Hamilton Depression Rating Scale), suicidality (Columbia Suicide Severity Rating Scale), adverse childhood experiences (ACES), and quality of life (Youth Quality of Life Instrument - Short Form) as part of a larger nationwide cross-sectional school-based epidemiological study. Internal consistency, construct validity, and diagnostic accuracy of the PHQ-A were evaluated. The area under the ROC curve (AUC) values for Major Depressive Disorder (MDD), Persistent Depressive Disorder (PDD), and Adjustment Disorder (AD) were examined separately.
RESULTS: The PHQ-A demonstrated high internal consistency (Cronbach's α = 0.89) and was positively associated with adverse childhood experiences (ρ = 0.11, p = 0.042), suicidality (ρ = 0.43, p < 0.001), and depressive symptoms (ρ = 0.63, p < 0.001), and negatively associated with quality of life (ρ = -0.59, p < 0.001). The performance of the PHQ-A was acceptable for MDD (AUC = 0.79, 95 % CI = 0.72 - 0.85) but poorer for PDD (AUC = 0.68, 95 % CI = 0.58 - 0.77) and AD (AUC = 0.53, 95 % CI = 0.41 - 0.65).
CONCLUSION: The PHQ-A shows acceptable psychometric properties for screening for diagnosis of MDD, but not for PDD or AD, among English-speaking Asian adolescents. A cut-off score of ≥ 10 for MDD is recommended.
METHODS: 323 English-speaking Singaporean adolescents completed the PHQ-A, Kiddie Schedule for Affective Disorders and Schizophrenia Present and Lifetime Version (K-SADS-PL), and measures of depressive symptoms (Hamilton Depression Rating Scale), suicidality (Columbia Suicide Severity Rating Scale), adverse childhood experiences (ACES), and quality of life (Youth Quality of Life Instrument - Short Form) as part of a larger nationwide cross-sectional school-based epidemiological study. Internal consistency, construct validity, and diagnostic accuracy of the PHQ-A were evaluated. The area under the ROC curve (AUC) values for Major Depressive Disorder (MDD), Persistent Depressive Disorder (PDD), and Adjustment Disorder (AD) were examined separately.
RESULTS: The PHQ-A demonstrated high internal consistency (Cronbach's α = 0.89) and was positively associated with adverse childhood experiences (ρ = 0.11, p = 0.042), suicidality (ρ = 0.43, p < 0.001), and depressive symptoms (ρ = 0.63, p < 0.001), and negatively associated with quality of life (ρ = -0.59, p < 0.001). The performance of the PHQ-A was acceptable for MDD (AUC = 0.79, 95 % CI = 0.72 - 0.85) but poorer for PDD (AUC = 0.68, 95 % CI = 0.58 - 0.77) and AD (AUC = 0.53, 95 % CI = 0.41 - 0.65).
CONCLUSION: The PHQ-A shows acceptable psychometric properties for screening for diagnosis of MDD, but not for PDD or AD, among English-speaking Asian adolescents. A cut-off score of ≥ 10 for MDD is recommended.