Ocular immunology and inflammation · 2026
Racial Disparities Associated with Non-Infectious Anterior Uveitis and Concurrent Ocular Conditions: Results from a Large Multi-Institutional Research Network.
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Oyeniran Enny, Ramesh Abhisri, Raiker Rahul, Pakhchanian Haig, Akinbolue Daniel, Lee Cecilia S, Chew Emily Y, Elam Angela, Sen H Nida, Bellur Sunil, Kodati Shilpa
Аннотация
PURPOSE: To examine the differences between non-Hispanic White patients and other racial/ethnic groups and their likelihood of concurrent diagnosis with non-infectious anterior uveitis (AU) and other ocular conditions.
METHODS: The TriNetX database was used to identify adult patients with an incident diagnosis of non-infectious AU using ICD-10 codes. Non-Hispanic White patients with AU were compared to three groups (non-White, Black, and Hispanic patients). Odds ratios and 95% CIs for ocular conditions at the time of diagnosis with AU were compared between cohorts to evaluate the likelihood of a concurrent diagnosis with another ocular condition.
RESULTS: In the first group, Non-Hispanic White patients had greater odds of legal blindness (OR: 1.994; 95% CI: 1.5882.503) and epiretinal membrane (OR: 1.794; 95% CI: 1.514-2.126) compared to non-White patients. In the second group, Non-Hispanic White patients had lower odds of glaucoma (OR: 0.853; 95% CI: 0.805-0.904), glaucoma suspect (OR: 0.797; 95% CI: 0.735-0.864), and open angle glaucoma (OR: 0.53; 95% CI: 0.460-0.611) compared to Black patients. In the third group, Non-Hispanic White patients had lower odds of cataracts (OR: 0.755; 95% CI: 0.604-0.945), glaucoma (OR:0.706; 95% CI: 0.574-0.868), and glaucoma suspect (OR: 0.743; 95% CI: 0.557 -0.991) compared to Hispanic patients.
CONCLUSION: Non-Hispanic White patients diagnosed with AU had higher odds of legal blindness, and epiretinal membrane compared to non-White patients. Black and Hispanic patients were more likely to have glaucoma-related conditions at the time of AU diagnosis.
METHODS: The TriNetX database was used to identify adult patients with an incident diagnosis of non-infectious AU using ICD-10 codes. Non-Hispanic White patients with AU were compared to three groups (non-White, Black, and Hispanic patients). Odds ratios and 95% CIs for ocular conditions at the time of diagnosis with AU were compared between cohorts to evaluate the likelihood of a concurrent diagnosis with another ocular condition.
RESULTS: In the first group, Non-Hispanic White patients had greater odds of legal blindness (OR: 1.994; 95% CI: 1.5882.503) and epiretinal membrane (OR: 1.794; 95% CI: 1.514-2.126) compared to non-White patients. In the second group, Non-Hispanic White patients had lower odds of glaucoma (OR: 0.853; 95% CI: 0.805-0.904), glaucoma suspect (OR: 0.797; 95% CI: 0.735-0.864), and open angle glaucoma (OR: 0.53; 95% CI: 0.460-0.611) compared to Black patients. In the third group, Non-Hispanic White patients had lower odds of cataracts (OR: 0.755; 95% CI: 0.604-0.945), glaucoma (OR:0.706; 95% CI: 0.574-0.868), and glaucoma suspect (OR: 0.743; 95% CI: 0.557 -0.991) compared to Hispanic patients.
CONCLUSION: Non-Hispanic White patients diagnosed with AU had higher odds of legal blindness, and epiretinal membrane compared to non-White patients. Black and Hispanic patients were more likely to have glaucoma-related conditions at the time of AU diagnosis.