Neurologia · 2022
Intercritical photophobia in the migrainous patient. Proposal for diagnostic criteria.
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Ly-Yang F, Gómez-Calleja V, Pérez-García P, González-Gómez N, Porta-Etessam J, Santos-Bueso E
Аннотация
INTRODUCTION: Photophobia is a symptom of abnormal light intolerance without pain sensation that requires an anamnesis and an examination to diagnose an underlying etiology.
BASIC PROCEDURE: This article focuses on 30 clinical cases with isolated intense photophobia and on the review of the literature.
OBJECTIVE: The purpose of this article is to establish diagnostic criteria for photophobia.
RESULTS: The etiology of photophobia appears to be at the level of the intrinsically photosensitive retinal ganglion cells known as melanopsin cells and at a neurochemical level mediated by calcitonin-related peptide and the pituitary activating peptide cyclase.
CONCLUSION: The treatment of photophobia could consist of monoclonal antibodies against calcitonin-related peptide and/or pituitary activating peptide cyclase.
BASIC PROCEDURE: This article focuses on 30 clinical cases with isolated intense photophobia and on the review of the literature.
OBJECTIVE: The purpose of this article is to establish diagnostic criteria for photophobia.
RESULTS: The etiology of photophobia appears to be at the level of the intrinsically photosensitive retinal ganglion cells known as melanopsin cells and at a neurochemical level mediated by calcitonin-related peptide and the pituitary activating peptide cyclase.
CONCLUSION: The treatment of photophobia could consist of monoclonal antibodies against calcitonin-related peptide and/or pituitary activating peptide cyclase.