[Clinical application of bisphosphonates, present and future].

For the present, bisphosphonates are widely applicable;secondary osteoporosis, metastatic bone diseases, primary hyperparathyroidism, osteogenesis imparfecta, inflammatory bone and joint disorders besides primary osteoporosis, hypercalcemia of malignancy, Paget's disease of bone, and so on. More expansion of its clinical application in the future is greatly expected with elucidation of the mechanism of action.