Circulation journal : official journal of the Japanese Circulation Society · 2017
Relaxin and Matrix Metalloproteinase-9 in Angiotensin II-Induced Abdominal Aortic Aneurysms.
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Howatt Deborah A, Dajee Maya, Xie Xiaojie, Moorleghen Jessica, Rateri Debra L, Balakrishnan Anju, Da Cunha Valdeci, Johns Douglas G, Gutstein David E, Daugherty Alan, Lu Hong
Аннотация
BACKGROUND: This study determined whether relaxin or matrix metalloproteinase (MMP)-9 influences angiotensin II (AngII)-induced abdominal aortic aneurysms (AAA).
METHODS AND RESULTS: Male C57BL/6 or apolipoprotein E-/-mice were infused with AngII with or without relaxin. Relaxin did not influence AngII-induced AAA in either mouse strain. Infusion of AngII reduced, but relaxin increased, MMP-9 mRNA in macrophages. We then determined the effects of MMP-9 deficiency on AAA in apolipoprotein E-/-mice. MMP-9 deficiency led to AAA formation in the absence of AngII, and augmented AngII-induced aortic rupture and AAA incidence.
CONCLUSIONS: MMP-9 deficiency augmented AngII-induced AAA.
METHODS AND RESULTS: Male C57BL/6 or apolipoprotein E-/-mice were infused with AngII with or without relaxin. Relaxin did not influence AngII-induced AAA in either mouse strain. Infusion of AngII reduced, but relaxin increased, MMP-9 mRNA in macrophages. We then determined the effects of MMP-9 deficiency on AAA in apolipoprotein E-/-mice. MMP-9 deficiency led to AAA formation in the absence of AngII, and augmented AngII-induced aortic rupture and AAA incidence.
CONCLUSIONS: MMP-9 deficiency augmented AngII-induced AAA.